P-026 Effect of Microsurgical Varicocele Ligation in Patients with Isolated Oligozoospermia

Abstract Study question Is varicocelectomy effective in improving the semen quality of patients with isolated oligozoospermia (IO)? Summary answer Varicocelectomy is a valid option for infertile men clinical varicocele and documented IO considering significant improvement concentration. What known already Varicocele leading correctable cause male factor infertility its surgical treatment has been associated sound fertility potential. While clearly indicated abnormal parameters, effect on abnormalities less commonly assessed. design, size, duration The charts 1521 who underwent microsurgical subinguinal clinically palpable between 2011-2021 were retrospectively reviewed. Infertile included study group, while data from oligoasthenoteratozoospermia (OAT) utilized comparison. Participants/materials, setting, methods Men azoospermia, history genitourinary infection, those utilizing peri-operative medications excluded. collected patient's demographics, grade veins’ sizes, their (semen analysis, WHO 2010; sperm DNA fragmentation, Halosperm) hormone parameters before up to 6 months after varicocelectomy. Data analyzed using Wilcoxon Signed Ranks test chi-squared tests. A p value <0.05 was considered significant. Main results role chance total 96 123 OAT study. Patients had mean age 32.5 ± 7 years, an average testis volume 15.6ml. grades 2 3 58% 38% patients. Among increase concentration identified postoperatively (p = 0.01). Surprisingly, revealed decrease motility, however, postoperative median still within normal range (45.5%). No changes observed other or parameters. When comparison made 83% compared 63.9% group following (P 0.044). However, higher percentage showed motility among (67.6%) (42.9%) 0.04). Limitations, reasons caution Results obtained relatively small sample size. not necessarily as first mild derangements quality. Wider implications findings this shed light hence may be beneficial patient counselling clinic. Trial registration number applicable